I'm having an issue getting Exchange 2010 SP1 not use two NICs which will be dedicated for iSCSI. Every time I enable the iSCSI NICs Exchange develops connectivity issues.
I have disabled Client for Microsoft Networks, File and Print Sharing, and IPv6 on the iSCSI NICs. I also changed the connection order to ensure that the primary NIC was on top. I restarted the box after that change.
Whenever I enabled the iSCSI NICs Exchange reported three Event ID 2102 MSExchange ADAccess errors reporting it could no longer see the domain controllers. Is there some Powershell cmdlet I'm missing that tells Exchange to only use the primary NIC?